• Paxilline kinase A novel series of DHODH inhibitors was deve

  2019-09-16

  

  A novel series of DHODH inhibitors was developed by us based on a lead that was discovered during a docking procedure and medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method and yielded low nanomolar inhibitors. Introduction The most common metabolic h

• br Materials and methods br Results br

  2019-09-16

  

  Materials and methods Results Discussion In this paper, we have demonstrated application of the glmS ribozyme reverse genetic tool for chemogenomic profiling in Plasmodium spp. This tool can provide robust attenuation of expression for different target genes, across different strains varyin

• br Electron transfer pathway Intramolecular or inter

  2019-09-16

  

  Electron transfer pathway Intramolecular (or inter-domain) electron transfer (IET) in CDH has been studied in much depth [], and similar IET occurs in CcPDH, from the PQQ cofactor in the AA12 domain to the heme b in the AA8 domain. When two kinds of electron acceptors are used for measuring enzym

• Cysteine protease inhibitors representing several chemical s

  2019-09-16

  

  Cysteine protease inhibitors representing several chemical scaffold types are effective in halting parasite replication without toxicity to the host (Renslo and McKerrow, 2006). A vinyl sulfone cysteine protease inhibitor, K11777, is completing final Good Laboratory Practice (GLP) preclinical tests

• In conclusion our work led to the characterization of

  2019-09-16

  

  In conclusion, our work led to the characterization of some signalling events of the CysLT1 receptor variants, at several levels, and showed that a punctual serine mutation could alter the response of receptors to cysLTs. Although atopy is a complex phenotype implicating different cell types, mediat

• In contrast irinotecan has shown

  2019-09-12

  In contrast, irinotecan has shown much less myelosuppression and may be more active in Ewing sarcoma both alone and in combination with temozolamide.

• The effect of the simple dopaminergic tonic phasic model

  2019-09-11

  The effect of the simple dopaminergic tonic/phasic model on cognitive processing has been investigated by a few studies (Nolan et al., 2004; Rosa et al., 2010).

• Results are expressed as mean s

  2019-09-10

  Results are expressed as mean±s.e.m. Paired or unpaired Student\'s t test was used for comparisons between 2 groups and one-way ANOVA followed by Bonferroni\'s post-test for more groups.

• The interest for lanthanide and

  2019-09-09

  The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM).

• GNF 5 br Analytical improvements Since our review of Oxyster

  2019-09-07

  Analytical improvements Since our review of “Oxysterol Metabolomes” in 2011 [7], there have been a number of improvements in analytical methods for the analysis of oxysterols and related compounds.

• LTD and LTC cause contraction in the rat stomach and

  2019-09-06

  LTD4 and LTC4 cause contraction in the rat stomach and these contractions are sensitive to CysLT1 receptor antagonists (Goldenberg and Subers, 1983, Miura et al., 1992, Miyata et al., 1995).

• br Conflicts of interest br Author

  2019-09-05

  Acknowledgements This work was supported by the University of Brescia (ex 60%) and Siderurgica Leonessa research funds to AF.

• The associations between genetic factors and socio emotional

  2019-09-04

  The associations between genetic factors and socio-emotional functioning are complex and almost certainly not direct.

• br Experimental procedures br Results

  2019-09-03

  Results Fluorescence attributable to GnRH-eGFP neurons was observed through the diagonal band of Broca, to the POA of the hypothalamus in GnRH-eGFP transgenic rats for all groups as described previously (Kato et al., 2003, Tada et al., 2013).

• The efficacy of A in

  2019-09-02

  The efficacy of A-922500 in the ob/ob mouse model is of particular interest for two reasons. One of the most striking features of the DGAT-1 deficient mouse phenotype is the resistance to diet-induced obesity (Smith et al., 2000).

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