• The associations between genetic factors and socio emotional

  2019-09-04

  The associations between genetic factors and socio-emotional functioning are complex and almost certainly not direct.

• br Experimental procedures br Results

  2019-09-03

  Results Fluorescence attributable to GnRH-eGFP neurons was observed through the diagonal band of Broca, to the POA of the hypothalamus in GnRH-eGFP transgenic rats for all groups as described previously (Kato et al., 2003, Tada et al., 2013).

• The efficacy of A in

  2019-09-02

  The efficacy of A-922500 in the ob/ob mouse model is of particular interest for two reasons. One of the most striking features of the DGAT-1 deficient mouse phenotype is the resistance to diet-induced obesity (Smith et al., 2000).

• AMD is equally active against a broad

  2019-08-30

  AMD3100 is equally active against a broad range of HIV-1 and HIV-2 strains, but not against simian immunodeficiency virus (SIV) strains in human PBMC (De Clercq et al., 1994).

• Potential break through technology poised to overcome these

  2019-08-29

  Potential break-through technology poised to overcome these above-mentioned limitations is that of the “substrate mediated enzyme prodrug therapy”, SMEPT (Fig. 1).

• In agreement with the study

  2019-08-28

  In agreement with the study on porcine microsomes (Ekstrand et al., 2015), our results indicated a somewhat higher degree of inhibition of CYP2E1 activity in the male pools compared to females.

• Gupta et al have shown that a

  2019-08-27

  Gupta et al have shown that a genetic variant associated with the 5 vascular diseases (coronary artery disease, migraine, carotid artery dissection, fibro-muscular dysplasia, and hypertension) is a distal regulator of the ET-1 gene [30].

• The use of inhibitors clearly has its caveats

  2019-08-26

  The use of inhibitors clearly has its caveats and the field should come to a consensus on etomoxir concentration to maximally block LC-FAO while minimalizing off-target effects.

• Modulating protein stability specifically inhibiting ubiquit

  2019-08-24

  Modulating protein stability, specifically inhibiting ubiquitin E3 ligases, provides potential advantages over other druggable targets given the presence of biochemically multiple, unique pharmacophores within complexes that can bind a variety of small molecules [12].

• Accumulated evidence indicates that apelin plays a protectiv

  2019-08-23

  Accumulated evidence indicates that apelin plays a protective role in ischemic stroke, contributing to post-stroke recovery (Yang et al., 2014; Chen et al., 2015; Xin et al., 2015; Yan et al., 2015).

• Although the amino acid sequences of CUL A and CUL

  2019-08-22

  Although the amino Icotinib sequences of CUL4A and CUL4B share 82% identity, the existing studies have shown that these two proteins do not have significant functional redundancy.

• PGE EP activation has been found to attenuate

  2019-08-21

  PGE2-EP4 activation has been found to attenuate the activation of microglia and to prevent lipid peroxidation and pro-inflammatory gene expression in a murine model of lipopolysaccharide (LPS)-induced Erythromycin inflammation [15].

• Treatment with ICIs is often accompanied by severe

  2019-08-20

  Treatment with ICIs is often accompanied by severe adverse events, referred to as irAEs, such as rash, pneumonitis, hepatitis, autoimmune diabetes, and colitis [13].

• br Materials and methods br

  2019-08-19

  Acknowledgments This work was supported by grants from National 973 Project (2015CB755700) and the Doctoral Starting up Foundation of Henan University of Science and Technology (13480033).

• Another important consideration with respect to drug

  2019-08-17

  Another important consideration with respect to drug conditioning suggested by the present findings is the observation of an attenuated SKLB610 on the second extinction trial.

14165 records 944/945 page Previous Next First page 上5页 941942943944945