• Because stimulation and blockade of dopamine D

  2020-11-27

  

  Because stimulation and blockade of dopamine D2 receptor all cause a similar disruption of maternal behavior, one critical question is whether they do so through the same or different behavioral mechanisms. One idea is that stimulation or blockade of D2 receptors similarly suppresses maternal motiva

• The larger eukaryotic ligases such as LigI and

  2020-11-27

  

  The larger eukaryotic ligases, such as LigI and LigIV, also possess an additional N-terminal DNA-binding domain (DBD) that is required for efficient ligation (Fig. 1c) and enables these ligases to encircle DNA [17]. An equivalent helix–hairpin–helix domain is also present in the bacterial NAD-depend

• Previous studies showed that many steroidogenic enzymes act

  2020-11-26

  

  Previous studies showed that many steroidogenic enzymes act when the enzyme binds to the cofactor first [30]. In the present study, we showed that HPTE inhibited both AKR1C14 and RDH2 in a mixed mode when cofactor was used. This indicates that HPTE interferes with cofactor-binding residues although

• To determine direct DDR binding partners and to further conn

  2020-11-26

  

  To determine direct DDR1-binding partners and to further connect to Akt and mTOR signaling, we performed mass spectrometry on DDR1 immunoprecipitates and found various candidates of the Akt and mTOR pathway such as LARP1 (La-related protein 1) and RPS6 (40S ribosomal protein S6/ S6). Most intriguing

• Our recent discovery M P H R A

  2020-11-26

  

  Our recent discovery (M.P., H.R., A.S.) of a highly selective and in vivo active DDR1 small-molecule inhibitor provides evidence that DDR1 is a druggable pharmaceutical target, and some details of our efforts are provided below. To avoid the repurposing of known kinase inhibitor structural motifs, w

• Studies of LRRK tagged with green fluorescent

  2020-11-26

  

  Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the Tylosin phosphate of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 defines it

• Oral antipsychotics are substrates of

  2020-11-26

  

  Oral antipsychotics are substrates of CYP450 enzymes, which are crucial to their metabolism and elimination (Fig. 1). The efficacy and toxicity of antipsychotic agents is affected by factors that induce or inhibit CYP450 expression and function, such as drug–drug interactions. Additionally, the mult

• In the present study the expression of the

  2020-11-26

  

  In the present study, the ptio of the CYP2C11 gene and the levels of its protein and activity were decreased in rats with liver insufficiency and in rats after induced dysfunction of the serotonergic system during normal liver function. Moreover, serotonergic system dysfunction during liver insuffi

• The V V process of the FPGA development includes equivalence

  2020-11-26

  

  The V&V process of the FPGA development includes equivalence checking (Huang and Cheng, 1998, Huang et al., 2000, Kuehlmann and Krohm, 1997, Kuehlmann et al., 1995, Burch et al., 1994) as well as the simulation techniques. The equivalence checking can prove that two given designs have the same funct

• Following Duncan as a ritualized site Tyne Cot provides

  2020-11-26

  

  Following Duncan (1995), as a ritualized site Tyne Cot provides an opportunity for individual tourists to conduct their own acts of remembrance (Edensor, 2000, Iles, 2006). The analysis has also shown that individual acts of writing particular words and phrases in the visitor books are socially shar

• Decanoyl-RVKR-CMK australia Meanwhile high levels of extrave

  2020-11-26

  

  Meanwhile, high levels of extraversion have been associated with weaker conditioning and faster Decanoyl-RVKR-CMK australia learning (Eysenck, 1970). Similar to neuroticism/anxiety, the role of extraversion for fear conditioning and extinction has found only limited empirical support (Rauch et al.,

• In the present study we did not examine whether

  2020-11-26

  

  In the present study, we did not examine whether the CpG site-specific COMT methylation are associated with any genetic variants in response to E2, GEN or SFN. Some studies suggest that oxidative DNA damage causes genetic variation which may induce epigenetic changes that lead to gene silencing (Kho

• Materials and methods br Results br

  2020-11-26

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino Emodin synthesis for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the e

• br Acknowledgements This work was supported by National

  2020-11-26

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec

• Tibolone is also efficacious on bone in

  2020-11-26

  

  Tibolone is also efficacious on bone in elderly women and induces a clear reduction in bone turnover markers [50], [51]. Rymer et al. showed that, after 10 years of treatment with tibolone, the difference in bone mineral density compared with a placebo group was more than 12% for both lumbar spine a

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