• Two excellent GSMs with clear pharmacological effect across

  2022-08-23

  

  Two excellent GSMs with clear pharmacological effect across rats, dogs, monkeys, and human subjects are BMS-932481 and BMS-986133 with IC50 at 6.6 and 3.5 nM to reduce Aβ42, respectively. Both GSMs exhibit dose- and time-dependent activity in vivo by decreasing Aβ1-42 and Aβ1-40 levels while increas

• The second experiment investigated the possible neuronal

  2022-08-23

  

  The second experiment investigated the possible neuronal mechanism underlying the effect of acupuncture. The baseline level of methamphetamine consumption in each group was similar, as in the first experiment (Fig. 2A). Acupuncture at HT7 also significantly inhibited the methamphetamine self-adminis

• br ACKNOWLEDGMENTS br Introduction Odorant

  2022-08-23

  

  ACKNOWLEDGMENTS Introduction Odorant receptors (ORs) are the largest subfamily of G protein-coupled receptors (GPCRs) and are mainly expressed by olfactory sensory neurons in the nose for the detection of various odorants [1]. However, more recent reports suggest that ORs are also expressed an

• br Results br Discussion The present findings outline

  2022-08-22

  

  Results Discussion The present findings outline a novel regulatory mechanism for fasting-induced ketogenesis, which involves histamine release from mast akt pathway into the hepatic portal system, H1 receptor-mediated stimulation of liver OEA biosynthesis, and recruitment of the nuclear recep

• Maillard reaction also known as non enzymatic browning react

  2022-08-22

  

  Maillard reaction, also known as non-enzymatic browning reaction, is a complex chemical reaction between carbonyl groups of reducing sugars and free amino groups of amino acids, peptides, proteins or some other nitrogen containing compounds. Maillard reaction plays an important role in food industry

• Hypoxia HIF and Inflammation Cellular responses

  2022-08-22

  

  Hypoxia, HIF, and Inflammation Cellular responses to hypoxia are essential for life and are now recognized to be dysregulated in a wide range of disease processes. The key players in these pathways are a family of transcription factors, the hypoxia-inducible factors (HIFs; see Glossary), as well as

• br Statistical analysis The mean standard deviation

  2022-08-22

  

  Statistical analysis The mean, standard deviation, median, range, frequency, and percentage were used for data description. The chi-square (x2) test was used for analyses the differences in categorical variables in the 2-way table. Overall survival (OS) was defined as the time interval between t

• Most importantly proteomics analyses have been

  2022-08-22

  

  Most importantly, proteomics analyses have been incorporated in the study of numerous endocrine diseases that appear or may appear in childhood, starting from the stage of the early fetus to the universally applied newborn screening programs and to adolescence, and shedding light on the molecular pa

• Molecular modeling studies also revealed insignificant diffe

  2022-08-22

  

  Molecular modeling studies also revealed insignificant differences in ligand-receptor interaction energies between R and S enantiomers of LPCs or their 2-OMe-analogues, suggesting that enantiomers of a particular structure should exert similar GPR119-mediated biological effect. Indeed, when studied

• br Introduction In the treatment of patients

  2022-08-22

  

  Introduction In the treatment of patients with AIDS and human immunodeficiency virus type 1 (HIV-1), anti-retroviral therapy (ART), which uses anti-HIV drugs such as protease inhibitors, integrase inhibitors and reverse transferase inhibitors, has made a major contribution. There are still some s

• Mongolian gerbils Meriones unguiculatus a social rodent spec

  2022-08-22

  

  Mongolian gerbils (Meriones unguiculatus), a social rodent species, are widely distributed in the typical steppe, desert steppe and desert habitats of northern China, Mongolia, and Trans-Baikal region of Russia. In wild, the recorded maximum lifespan (apparent longevity) was 29.5 months for female M

• The synthesis of is shown in

  2022-08-22

  

  The synthesis of is shown in . The ---Boc--diaminopropanoic acid--butyl ester () fragment was synthesized in four steps from Boc--asparagine (). The key step in this synthesis was a Hofmann rearrangement of the terminal carboxamide, which was performed according to the elegant protocol of Zhang that

• Crystal structure of CD LEL have revealed the head

  2022-08-22

  

  Crystal structure of CD81-LEL have revealed the head sub-domain to be implicated in binding to HCV (Kitadokoro et al., 2001). In a study using African green monkey CD81, T163A, F186 L, E188K and D196E mutations disrupted HCV E2 binding (Higginbottom et al., 2000). In our docking studies, T163 and D1

• CGRP (rat) receptor br Regulation of Glu transporters

  2022-08-22

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino CGRP (rat) receptor calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include

• br Introduction The nature of chemotherapies is

  2022-08-19

  

  Introduction The nature of chemotherapies is to relieve the tumor burden of the patients by eliminating cancer Daidzein via inducing cell death, mostly regulated cell death represented by apoptosis [1,2]. Dozens of anticancer agents including clinically used ones kill cancer cells by promoting a

14213 records 370/948 page Previous Next First page 上5页 366367368369370 下5页 Last page